Seamless networks of myocardial bioenergetics in the in vivo heart

Jianyi (Jay) Zhang, MD, PhD
Medicine and Biomedical Engineering Professor
Division of Cardiology
University of Minnesota

Abstract
Participants will be able to discuss and explain the current understanding of myocardial bioenergetics in normal heart, and in hearts of postinfarction LV remodeling with or without stem cell transplantation. They will also discuss the potential mechanisms of beneficial effects of cellular therapy for the injured heart. Participants will share their knowledge and interests in NMR imaging and spectroscopy, and in pursuing the novel applications in the emerging field of cellular therapy.

Biography
Jianyi (Jay) Zhang (zhang047@umn.edu) is a Professor of Medicine and Biomedical Engineering, Division of Cardiology, Department of Medicine, University of Minnesota Medical school. He graduated Shanghai Medical University, Shanghai, PRC; received Master of Science, School of Engineering, Tufts University, Medford, Massachusetts; and Biomedical Engineering, Institute of Technology Graduate School, University of Minnesota. Dr. Zhang received Post-doctoral training in Cardiology, University of Minnesota. Research Interests include myocardial energetics in hearts with postinfarction LV remodeling and congestive heart failure, biomaterials, and Stem Cells for Cardiac Repair. Dr. Zhang received an Established Investigator Award ( EIA, 1996) from American Heart Association (AHA) and NIH First Award from National Institutes of Health (FIRST, 1994). He is currently a principal investigator (PI) of three RO1 grants from NIH through 2016 in the fields of Myocardial Bioenergetics, biomaterial and Stem cells for Cardiac Repair, respectively; he also Co-PI of 2 other program grants. Over the years, Zhang research lab has trained more than 40 trainees (PhD, Post-Doc, residents, and cardiology fellows), and led 11 PhDs in biomedical engineering, physiology, or electrical engineering. Dr. Zhang is currently advisor to three PhD students earning their PhD in Biomedical Engineering, Physiology, or Electrical engineering, respectively. Professional Organizations: Fellow members in American Physiological Society, American Heart Association. Reviewer on NIH study sections (MIM, Charter member); Scientific Journal editorial board member for: Circulation Research, American Journal of Physiology. Several representative publications from his studies include:
• Xiong Q, Du F, Zhang P, Chen W, Zhang J (2011). ATP production rate via CK or ATP synthase in vivo: a novel superfast magnetization saturation transfer method . Circulation Research 2011, 108(6):653-63
• Xiong Q, Ye L, Zhang P, Lepley M, Swingen C, Zhang L, Kaufman DS, Zhang J. Bioenergetic and functional consequences of cellular therapy: activation of endogenous cardiovascular progenitor cells. Circ Res. 2012 Aug 3;111(4):455-68
• Xiong Q, Ye L, Zhang P, Lepley M, Tian J, Li J, Zhang L, Swingen C, Vaughan JT, Kaufman DS, Zhang J. Functional Consequences of Human Induced Pluripotent Stem Cells Therapy: Myocardial ATP Turnover Rate in the in vivo Swine Hearts with Post-Infarction Remodeling. Circulation. 2013;127(9):997-1008
•  Ye L, Zimmermann WH, Garry DJ, Zhang J. Patching the Heart: Cardiac Repair from Within and Outside. Circulation Research 2013 (in press)
•  Ye L, Xiong Q, Zhang P, Su L, Zhang J. Thymosin β4 increases the potency of transplanted mesenchymal stem cells for myocardial repair. Circulation. 2013 (in press)
•  Zhang J. The mechanisms of cell therapy for clinical investigations: an urgent need for large-animal models Circulation. 2013 Jul 9;128(2):92-4